Conservation Law Analysis in Numerical Schema for a Tumor Angiogenesis PDE System

Pasquale De Luca () and Livia Marcellino
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Pasquale De Luca: International PhD Programme/UNESCO Chair “Environment, Resources and Sustainable Development”, Department of Science and Technology, Parthenope University of Naples, Centro Direzionale Isola C4, 80143 Naples, Italy
Livia Marcellino: International PhD Programme/UNESCO Chair “Environment, Resources and Sustainable Development”, Department of Science and Technology, Parthenope University of Naples, Centro Direzionale Isola C4, 80143 Naples, Italy

Mathematics, 2024, vol. 13, issue 1, 1-15

Abstract: Tumor angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a crucial process in cancer growth and metastasis. Mathematical modeling through partial differential equations helps to understand this complex biological phenomenon. Here, we provide a conservation properties analysis in a tumor angiogenesis model describing the evolution of endothelial cells, proteases, inhibitors, and extracellular matrix. The adopted approach introduces a numerical framework that combines spatial and time discretization techniques. Here, we focus on maintaining solution accuracy while preserving physical quantities during the simulation process. The method achieved second-order accuracy in both space and time discretizations, with conservation errors showing consistent convergence as the mesh was refined. The numerical schema demonstrates stable wave propagation patterns, in agreement with experimental observations. Numerical experiments validate the approach and demonstrate its reliability for long-term angiogenesis simulations.

Keywords: tumor angiogenesis; partial differential equations; numerical methods; numerical conservation (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2024
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