A Framework for Breast Cancer Classification with Deep Features and Modified Grey Wolf Optimization

Fathimathul Rajeena P.p () and Sara Tehsin ()
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Fathimathul Rajeena P.p: Computer Science Department, College of Computer Science and Information Technology, King Faisal University, Alhasa 31982, Saudi Arabia
Sara Tehsin: Faculty of Informatics, Kaunas University of Technology, 51368 Kaunas, Lithuania

Mathematics, 2025, vol. 13, issue 8, 1-30

Abstract: Breast cancer is the most common disease in women, with 287,800 new cases and 43,200 deaths in 2022 across United States. Early mammographic picture analysis and processing reduce mortality and enable efficient treatment. Several deep-learning-based mammography classification methods have been developed. Due to low-contrast images and irrelevant information in publicly available breast cancer datasets, existing models generally perform poorly. Pre-trained convolutional neural network models trained on generic datasets tend to extract irrelevant features when applied to domain-specific classification tasks, highlighting the need for a feature selection mechanism to transform high-dimensional data into a more discriminative feature space. This work introduces an innovative and effective multi-step pathway to overcome these restrictions. In preprocessing, mammographic pictures are haze-reduced using adaptive transformation, normalized using a cropping algorithm, and balanced using rotation, flipping, and noise addition. A 32-layer convolutional neural model inspired by YOLO, U-Net, and ResNet is intended to extract highly discriminative features for breast cancer classification. A modified Grey Wolf Optimization algorithm with three significant adjustments improves feature selection and redundancy removal over the previous approach. The robustness and efficacy of the proposed model in the classification of breast cancer were validated by its consistently high performance across multiple benchmark mammogram datasets. The model’s constant and better performance proves its robust generalization, giving it a powerful solution for binary and multiclass breast cancer classification.

Keywords: deep learning; mammography; breast cancer; grey wolf algorithm; optimization (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2025
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