Recurrent Neural Network-Based Model Predictive Control for Continuous Pharmaceutical Manufacturing

Wee Chin Wong, Ewan Chee, Jiali Li and Xiaonan Wang
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Wee Chin Wong: Department of Chemical & Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore
Ewan Chee: Department of Chemical & Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore
Jiali Li: Department of Chemical & Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore
Xiaonan Wang: Department of Chemical & Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore

Mathematics, 2018, vol. 6, issue 11, 1-20

Abstract: The pharmaceutical industry has witnessed exponential growth in transforming operations towards continuous manufacturing to increase profitability, reduce waste and extend product ranges. Model predictive control (MPC) can be applied to enable this vision by providing superior regulation of critical quality attributes (CQAs). For MPC, obtaining a workable system model is of fundamental importance, especially if complex process dynamics and reaction kinetics are present. Whilst physics-based models are desirable, obtaining models that are effective and fit-for-purpose may not always be practical, and industries have often relied on data-driven approaches for system identification instead. In this work, we demonstrate the applicability of recurrent neural networks (RNNs) in MPC applications in continuous pharmaceutical manufacturing. RNNs were shown to be especially well-suited for modelling dynamical systems due to their mathematical structure, and their use in system identification has enabled satisfactory closed-loop performance for MPC of a complex reaction in a single continuous-stirred tank reactor (CSTR) for pharmaceutical manufacturing.

Keywords: pharmaceuticals; critical quality attributes (CQAs); recurrent neural networks; model predictive control (MPC); system identification (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2018
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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