Pulmonary Vein Activity Organization to Determine Atrial Fibrillation Recurrence: Preliminary Data from a Pilot Study

Raquel Cervigón, Javier Moreno, José Millet, Julián Pérez-Villacastín and Francisco Castells
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Raquel Cervigón: Escuela Politécnica, Universidad de Castilla-La Mancha, Camino del Pozuelo sn, 16071 Cuenca, Spain
Javier Moreno: Unidad de Arritmias, Servicio de Cardiología, Hospital Ramón y Cajal, Ctra. de Colmenar Viejo km. 9100, 28034 Madrid, Spain
José Millet: Instituto ITACA, Universitat Politècnica de València, Camino de Vera sn, 46022 Valencia, Spain
Julián Pérez-Villacastín: Unidad de Arritmias, Hospital Clínico San Carlos, Plaza de Cristo Rey sn, 28040 Madrid, Spain
Francisco Castells: Instituto ITACA, Universitat Politècnica de València, Camino de Vera sn, 46022 Valencia, Spain

Mathematics, 2020, vol. 8, issue 10, 1-13

Abstract: Ablation of pulmonary veins has emerged as a key procedure for normal rhythm restoration in atrial fibrillation patients. However, up to half of ablated Atrial fibrillation (AF) patients suffer recurrences during the first year. In this article, simultaneous intra-atrial recordings registered at pulmonary veins previous to the ablation procedure were analyzed. Spatial cross-correlation and transfer entropy were computed in order to estimate spatial organization. Results showed that, in patients with arrhythmia recurrence, pulmonary vein electrical activity was less correlated than in patients that maintained sinus rhythm. Moreover, correlation function between dipoles showed higher delays in patients with AF recurrence. Results with transfer entropy were consistent with spatial cross-correlation measurements. These results show that arrhythmia drivers located at the pulmonary veins are associated with a higher organization of the electrical activations after the ablation of these sites.

Keywords: spatial cross-correlation; transfer entropy; atrial fibrillation; ablation recurrence (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2020
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