Methodology to Calibrate the Dissection Properties of Aorta Layers from Two Sets of Experimental Measurements

Itziar Ríos-Ruiz, Myriam Cilla, Miguel A. Martínez and Estefanía Peña
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Itziar Ríos-Ruiz: Applied Mechanics and Bioengineering, Aragón Institute of Engineering Research (I3A), University of Zaragoza, 50018 Zaragoza, Spain
Myriam Cilla: Applied Mechanics and Bioengineering, Aragón Institute of Engineering Research (I3A), University of Zaragoza, 50018 Zaragoza, Spain
Miguel A. Martínez: Applied Mechanics and Bioengineering, Aragón Institute of Engineering Research (I3A), University of Zaragoza, 50018 Zaragoza, Spain
Estefanía Peña: Applied Mechanics and Bioengineering, Aragón Institute of Engineering Research (I3A), University of Zaragoza, 50018 Zaragoza, Spain

Mathematics, 2021, vol. 9, issue 14, 1-11

Abstract: Aortic dissection is a prevalent cardiovascular pathology that can have a fatal outcome. However, the mechanisms that trigger this disease and the mechanics of its progression are not fully understood. Computational models can help understand these issues, but they need a proper characterisation of the tissues. Therefore, we propose a methodology to obtain the dissection parameters of all layers in aortic tissue via the computational modelling of two different delamination tests: the peel and mixed tests. Both experimental tests have been performed in specimens of porcine aorta, where the intima-media and media-adventitia interfaces, as well as the medial layer, were dissected. These two tests have been modelled using a cohesive zone formulation for the separating interface and a hyperelastic anisotropic material model via an implicit static analysis. The dissection properties of each interface have been calibrated by reproducing the force-displacement curves obtained in the experimental tests. The values of peak and mean force of the experiments were fitted with an error below 10 % . With this methodology, we intend to contribute to the development of reliable numerical tools for simulating aortic dissection and aortic aneurysm rupture.

Keywords: aortic dissection; delamination tests; cohesive zone model; porcine aorta; vascular mechanics (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2021
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