Anatomical Model of Rat Ventricles to Study Cardiac Arrhythmias under Infarction Injury

Roman Rokeakh, Tatiana Nesterova, Konstantin Ushenin, Ekaterina Polyakova, Dmitry Sonin, Michael Galagudza, Tim De Coster, Alexander Panfilov and Olga Solovyova
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Roman Rokeakh: Almazov National Medical Research Centre, 197341 Saint-Petersburg, Russia
Tatiana Nesterova: Almazov National Medical Research Centre, 197341 Saint-Petersburg, Russia
Konstantin Ushenin: Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 620049 Ekaterinburg, Russia
Ekaterina Polyakova: Almazov National Medical Research Centre, 197341 Saint-Petersburg, Russia
Dmitry Sonin: Almazov National Medical Research Centre, 197341 Saint-Petersburg, Russia
Michael Galagudza: Almazov National Medical Research Centre, 197341 Saint-Petersburg, Russia
Tim De Coster: Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Alexander Panfilov: Almazov National Medical Research Centre, 197341 Saint-Petersburg, Russia
Olga Solovyova: Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 620049 Ekaterinburg, Russia

Mathematics, 2021, vol. 9, issue 20, 1-27

Abstract: Species-specific computer models of the heart are a novel powerful tool in studies of life-threatening cardiac arrhythmias. Here, we develop such a model aimed at studying infarction injury in a rat heart, the most common experimental system to investigate the effects of myocardial damage. We updated the Gattoni2016 cellular ionic model by fitting its parameters to experimental data using a population modeling approach. Using four selected cellular models, we studied 2D spiral wave dynamics and found that they include meandering and break-up. Then, using an anatomically realistic ventricular geometry and fiber orientation in the rat heart, we built a model with a post-infarction scar to study the electrophysiological effects of myocardial damage. A post-infarction scar was simulated as an inexcitable obstacle surrounded by a border zone with modified cardiomyocyte properties. For cellular models, we studied the rotation of scroll waves and found that, depending on the model, we can observe different types of dynamics: anchoring, self-termination or stable rotation of the scroll wave. The observed arrhythmia characteristics coincide with those measured in the experiment. The developed model can be used to study arrhythmia in rat hearts with myocardial damage from ischemia reperfusion and to examine the possible arrhythmogenic effects of various experimental interventions.

Keywords: cardiac modeling; cardiac simulation; rat heart; ventricular arrhythmia; myocardial infarction; post-infarction scar; ischemia (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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