Mass-Preserving Approximation of a Chemotaxis Multi-Domain Transmission Model for Microfluidic Chips

Elishan Christian Braun, Gabriella Bretti and Roberto Natalini
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Elishan Christian Braun: Department Mathematics, University of Rome 3, 00146 Rome, Italy
Gabriella Bretti: Istituto per le Applicazioni del Calcolo “M.Picone”, 00185 Rome, Italy
Roberto Natalini: Istituto per le Applicazioni del Calcolo “M.Picone”, 00185 Rome, Italy

Mathematics, 2021, vol. 9, issue 6, 1-34

Abstract: The present work is inspired by the recent developments in laboratory experiments made on chips, where the culturing of multiple cell species was possible. The model is based on coupled reaction-diffusion-transport equations with chemotaxis and takes into account the interactions among cell populations and the possibility of drug administration for drug testing effects. Our effort is devoted to the development of a simulation tool that is able to reproduce the chemotactic movement and the interactions between different cell species (immune and cancer cells) living in a microfluidic chip environment. The main issues faced in this work are the introduction of mass-preserving and positivity-preserving conditions, involving the balancing of incoming and outgoing fluxes passing through interfaces between 2D and 1D domains of the chip and the development of mass-preserving and positivity preserving numerical conditions at the external boundaries and at the interfaces between 2D and 1D domains.

Keywords: multi-domain network; transmission conditions; finite difference schemes; chemotaxis; reaction-diffusion models (search for similar items in EconPapers)
JEL-codes: C (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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