Allantoin from Valuable Romanian Animal and Plant Sources with Promising Anti-Inflammatory Activity as a Nutricosmetic Ingredient

Rodica Mihaela Dinica, Cristina Sandu, Andreea Veronica Dediu Botezatu, Anna Cazanevscaia Busuioc, Fanica Balanescu, Maria Daniela Ionica Mihaila, Caterina Nela Dumitru, Bianca Furdui and Alina Viorica Iancu
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Rodica Mihaela Dinica: Department of Chemistry Physical and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, 800201 Galati, Romania
Cristina Sandu: Department of Chemistry Physical and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, 800201 Galati, Romania
Andreea Veronica Dediu Botezatu: Department of Chemistry Physical and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, 800201 Galati, Romania
Anna Cazanevscaia Busuioc: Department of Chemistry Physical and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, 800201 Galati, Romania
Fanica Balanescu: Department of Chemistry Physical and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, 800201 Galati, Romania
Maria Daniela Ionica Mihaila: Department of Chemistry Physical and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, 800201 Galati, Romania
Caterina Nela Dumitru: Faculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 800010 Galati, Romania
Bianca Furdui: Department of Chemistry Physical and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, 800201 Galati, Romania
Alina Viorica Iancu: Faculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 800010 Galati, Romania

Sustainability, 2021, vol. 13, issue 18, 1-18

Abstract: Helix aspersa (HA), Helix pomatia (HP) and Symphytum officinale are common organisms in Romania’s biosphere, widely known for their allantoin content and their therapeutic properties. Herein, the allantoin was separated and quantified from the aqueous extracts of Romanian comfrey root and the secretions of HA and HP snails. This study also focused on determining the antioxidant and anti-inflammatory activities of these Romanian allantoin-rich samples. The plant extracts were obtained through two methods: ultrasonic extraction and enzymatic ultrasonic extraction. A microplate method was used for the quantitative determination of allantoin content. The antioxidant activity was measured by using the DPPH radical scavenging method. The antioxidant capacity of the samples was studied in order to observe the type of interactions generated by the chemical complex present in their composition. High concentrations of allantoin were obtained by enzymatic ultrasonic extraction method (EUE—102 ± 0.74 μg/mL), and also in the water-soluble fraction of the snail secretion (FS1—22.051 μg/mL). The antioxidant screening suggests that Symphytum officinale and snail mucus extracts could be used as promising natural substitutes for synthetic antioxidants in products used for therapeutic purposes. The evaluation of anti-inflammatory activity was also investigated, allantoin-rich samples showing a promising action (FS1—81.87 ± 2.34%). In future, the inclusion of allantoin-rich extracts in various novel pharmaceutical forms for new therapeutic applications could be achieved. The study will continue with the formulation of a nutricosmetic product with snail mucus and Symphytum officinale extract as principal bioactive ingredients.

Keywords: allantoin; Helix aspersa; Helix pomatia; Symphytum officinale; antioxidant activity; anti-inflammatory activity (search for similar items in EconPapers)
JEL-codes: O13 Q Q0 Q2 Q3 Q5 Q56 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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