Zinc-Silver Doped Mesoporous Hydroxyapatite Synthesized via Ultrasonic in Combination with Sol-Gel Method for Increased Antibacterial Activity

Piaw Phatai, Narid Prachumrak, Sirilak Kamonwannasit, Agarat Kamcharoen, Wuttichai Roschat, Sunti Phewphong, Cybelle Morales Futalan, Pongtanawat Khemthong, Teera Butburee, Saran Youngjan, Jeremiah C. Millare and Orrasa Prasitnok ()
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Piaw Phatai: Department of Chemistry, Faculty of Science, Udon Thani Rajabhat University, Udon Thani 41000, Thailand
Narid Prachumrak: Department of Chemistry, Faculty of Science, Udon Thani Rajabhat University, Udon Thani 41000, Thailand
Sirilak Kamonwannasit: Department of Agro-Industrial Product Development, Faculty of Agricultural Technology, Burapha University, Sakaeo 27160, Thailand
Agarat Kamcharoen: Department of Agro-Industrial Product Development, Faculty of Agricultural Technology, Burapha University, Sakaeo 27160, Thailand
Wuttichai Roschat: Program of Chemistry, Faculty of Science and Technology, Sakon Nakhon Rajabhat University, Sakon Nakhon 47000, Thailand
Sunti Phewphong: Biomass Energy Research Laboratory, Center of Excellence on Alternative Energy, Research and Development Institute, Sakon Nakhon Rajabhat University, Sakon Nakhon 47000, Thailand
Cybelle Morales Futalan: Department of Community and Environmental Resource Planning, University of the Philippines, Los Baños 4031, Philippines
Pongtanawat Khemthong: National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani 12120, Thailand
Teera Butburee: National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani 12120, Thailand
Saran Youngjan: National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani 12120, Thailand
Jeremiah C. Millare: School of Chemical, Biological, and Materials Engineering and Sciences, Mapua University, 658 Muralla St., Intramuros, Manila 1002, Philippines
Orrasa Prasitnok: Department of Chemistry, Faculty of Science, Mahasarakham University, Maha Sarakham 44150, Thailand

Sustainability, 2022, vol. 14, issue 18, 1-14

Abstract: Bone materials are mainly composed of an inorganic constituent called hydroxyapatite (HA). In the current study, mesoporous Zn 2+ /Ag + doped hydroxyapatite nanoparticles (Zn-Ag doped HA) with high antibacterial activity were synthesized through ultrasonic coupled sol-gel techniques under calcination temperatures of 600 °C for 4 h and 1100 °C for 1 h. The variance in the molar ratio of Zn 2+ /Ag + in Ca 9.0 Zn 1.0−x Ag x (PO 4 ) 6 (OH) 2 (x = 0.0, 0.25 to 1.0) and its effects on the chemical and physical properties of the powdered samples were investigated. The results show that the hexagonal framework of HA incorporated both the Zn 2+ and Ag + ions and the rhombohedral structure of β-TCP. The main functional groups of HA and Zn-Ag doped HA samples were hydroxyl and phosphate. All samples have mesoporous characteristics with a Type IV isotherm. The agar well diffusion process was used to examine antibacterial activity against E. coli , P. aeruginosa , S. aureus , B. cereus and B. subtilis . Effective antibacterial activity was displayed by Zn-Ag doped HA. Excellent antibacterial performance was shown by Ca 9.0 Zn 0.75 Ag 0.25 (PO 4 ) 6 (OH) 2 against all tested bacterial strains, except P. aeruginosa . This material showed inhibition zones ranging from 7 to 11 mm, implying that it is a suitable material with an antibacterial action for environmental applications, specifically for water purification.

Keywords: antibacterial activity; hydroxyapatite; silver; ultrasonic-assisted sol-gel technique; zinc (search for similar items in EconPapers)
JEL-codes: O13 Q Q0 Q2 Q3 Q5 Q56 (search for similar items in EconPapers)
Date: 2022
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