Time to Conquer Fungal Infectious Diseases: Employing Nanoparticles as Powerful and Versatile Antifungal Nanosystems against a Wide Variety of Fungal Species

Ali Jangjou, Zahra Zareshahrabadi, Milad Abbasi, Amirreza Talaiekhozani, Hesam Kamyab, Shreeshivadasan Chelliapan, Ahmad Vaez, Ali Golchin, Lobat Tayebi, Ehsan Vafa, Ali Mohammad Amani and Hossein Faramarzi ()
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Ali Jangjou: Department of Emergency Medicine, School of Medicine, Namazi Teaching Hospital, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran
Zahra Zareshahrabadi: Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran
Milad Abbasi: Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran
Amirreza Talaiekhozani: Department of Civil Engineering, Jami Institute of Technology, Isfahan 8491963395, Iran
Hesam Kamyab: Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, Kuala Lumpur 54100, Malaysia
Shreeshivadasan Chelliapan: Engineering Department, Razak Faculty of Technology & Informatics, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, Kuala Lumpur 54100, Malaysia
Ahmad Vaez: Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran
Ali Golchin: Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia 5714783734, Iran
Lobat Tayebi: School of Dentistry, Marquette University, Milwaukee, WI 53233, USA
Ehsan Vafa: Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran
Ali Mohammad Amani: Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran
Hossein Faramarzi: Department of Community Medicine, School of Medicine, Health Behavior Science Research Center, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran

Sustainability, 2022, vol. 14, issue 19, 1-33

Abstract: The development of novel antifungal agents and, in particular, the widespread use of these medications over the course of the past two decades, has had a significant impact on the treatment of fungal infectious diseases. This has resulted in a complete transformation of the treatment of fungal infectious diseases. However, the widespread development of antibiotic resistance has masked the significance of such breakthroughs. Antifungal infection treatment with nanoparticles has been shown to be effective. As a result of their unique characteristics, these substances, in contrast to antibiotics in their purest form, are able to exhibit an increased anti-proliferative capacity while requiring a lower concentration than traditional drugs do in order to achieve the same effect. Decreased drug effectiveness, minimal tissue penetration throughout tissue, restricted tissue penetration, decreased bioavailability, poor drug pharmacokinetics, and low water solubility are some of the major factors contributing to the employment of antifungal medicines in delivery systems. Because of this, one of the primary goals of incorporating antifungal medications into varying sorts of nanoparticles is to reduce the negative effects of the drugs’ inherent qualities. This article provides an overview of the many types of nanoparticles, such as metal, metal oxide, and non-metal oxide nanoparticles, carbon-based nanoparticles, nanostructured lipid carriers, polymeric nanoparticles, solid lipid nanoparticles, nanofibers, antifungal peptides, composites, and ZnO quantum dots, that can be used as antifungal drug delivery systems, as well as the benefits that these nanomaterials have over purified medications.

Keywords: antifungal activity; nanomaterials; drug delivery systems; infectious diseases (search for similar items in EconPapers)
JEL-codes: O13 Q Q0 Q2 Q3 Q5 Q56 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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