Fluorine-18 Fluorodeoxyglucose Isolation Using Graphene Oxide for Alternative Radiopharmaceutical Spillage Decontamination in PET Scan

Mohammad Khairul Azhar Abdul Razab, Norazlina Mat Nawi, Fara Hana Mohd Hadzuan, Nor Hakimin Abdullah, Maimanah Muhamad, Rosidah Sunaiwi, Fathirah Ibrahim, Farah Amanina Mohd Zin and An’amt Mohamed Noor
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Mohammad Khairul Azhar Abdul Razab: Medical Radiation Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Norazlina Mat Nawi: Department of Nuclear Medicine, Radiotherapy & Oncology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Fara Hana Mohd Hadzuan: Medical Radiation Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Nor Hakimin Abdullah: Advanced Materials Research Cluster, Faculty of Bioengineering and Technology, Universiti Malaysia Kelantan, Jeli Campus, Jeli 17600, Kelantan, Malaysia
Maimanah Muhamad: Nuclear Medicine & Molecular Imaging Department, Chancellor Tuanku Muhriz Hospital, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, Malaysia
Rosidah Sunaiwi: Medical Radiation Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Fathirah Ibrahim: Medical Radiation Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Farah Amanina Mohd Zin: Advanced Materials Research Cluster, Faculty of Bioengineering and Technology, Universiti Malaysia Kelantan, Jeli Campus, Jeli 17600, Kelantan, Malaysia
An’amt Mohamed Noor: Advanced Materials Research Cluster, Faculty of Bioengineering and Technology, Universiti Malaysia Kelantan, Jeli Campus, Jeli 17600, Kelantan, Malaysia

Sustainability, 2022, vol. 14, issue 8, 1-14

Abstract: Radiopharmaceuticals (RPC) used for diagnostic and therapeutic purposes in nuclear medicine may contaminate surface areas due to spillage during its preparation or accident during RPC transfer from laboratory to the treatment room. Fluorine-18 Fluorodeoxyglucose ( 18 F-FDG) is the most common RPC for positron emission tomography (PET) scan in nuclear medicine due to its ideal annihilation converted energy at 511 keV and short half-life at 109.8 min. Ineffective medical waste management of 18 F-FDG may pose a risk to the environment or cause unnecessary radiation doses to the personnel and public. Depending on the incident rate of these events, simple decontamination methods such as the use of chemicals and swabs might not be cost-effective and sustainable in the environment. This study aims to propose an alternative method to decontaminate 18 F-FDG by using graphene oxide (GO). GO was synthesised using the Hummers method while the physical morphology was analysed using a field emission scanning electron microscope (FESEM). 18 F-FDG adsorption efficiency rate using GO nanolayers was analysed based on the kinetic study of the GO: 18 F-FDG mixtures. The chemical adsorbability of the material was analysed via UV–vis spectrophotometer to interlink the microstructures of GO with the sorption affinity interaction. Resultantly, the adsorption rate was effective at a slow decay rate and the optical adsorption of GO with 18 F-FDG was dominated by the π → π * plasmon peak, which was near 230 nm. By elucidating the underlining GO special features, an alternative technique to isolate 18 F-FDG for the decontamination process was successfully proven.

Keywords: radiopharmaceutical; radioactive spillage; decontamination; radioactivity; adsorption; nuclear medicine (search for similar items in EconPapers)
JEL-codes: O13 Q Q0 Q2 Q3 Q5 Q56 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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