Heat Stress and Histopathological Changes of Vital Organs: A Novel Approach to Assess Climate Resilience in Farm Animals

Ebenezer Binuni Rebez, Veerasamy Sejian (), Mullakkalparambil Velayudhan Silpa and Frank R. Dunshea
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Ebenezer Binuni Rebez: Rajiv Gandhi Institute of Veterinary Education and Research, Kurumbapet, Pondicherry 605009, India
Veerasamy Sejian: Rajiv Gandhi Institute of Veterinary Education and Research, Kurumbapet, Pondicherry 605009, India
Mullakkalparambil Velayudhan Silpa: Institute of Animal Breeding and Genetics, Justus Liebig University Giessen, Ludwigstr. 21b, 35390 Giessen, Germany
Frank R. Dunshea: School of Agriculture and Food, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne, VIC 3010, Australia

Sustainability, 2023, vol. 15, issue 2, 1-28

Abstract: Heat stress causes functional and metabolic alterations in different cells and tissues. There are several pathomorphological changes and biomarkers associated with head load in adaptive and productive organs of livestock. Heat stress-induced histopathological alterations in livestock were categorized as degenerative changes (fatty degeneration, steatosis, hydropic degeneration), necrosis (pyknosis, fibrosis), circulatory disturbances (hyperemia, edema, hemorrhage, congestion, thrombosis, ischemia), growth disturbances (hyperplasia, atrophy) and focal/diffuse inflammation (vascular changes, exudation). Upon immunohistochemical analysis, the biomarkers identified in growth-related organs were HSP70 , HSP60 , GABA , GABA A R , GABA B R , HSP90 , GnRH , LH , FSH , m 6 A , Nrf2 , and C/EBPβ . The biomarkers in the reproductive organs were HSP70 , Bax , Bcl-2 , GABA , GABA A R , GABA B R , Caspase-3 , HSP90 , HSPB9 , HSPB10 , HSF1 , HSP40 , T , E 2 , Cyt-C , CAT , BCL2L1 , and VEGF. The identified biomarkers in the immune organs were CD3 + T cells , CD4 + T cells , CD8 + T cells , HSP70 , and Bcl-2 . All these biomarkers could serve as reliable variables in heat stress assessment in livestock. Further, HSP70 , HSP90 , HSP60 , NPY , HSP27 , Bcl-2 , NF-κB , AQP2 , Insulin , CD3 + T cells , CD4 + T cells , CD172a , EGF , AQP1 , AQP3 , AQP4 , AQP5 , CRYAB , GHR , 5-HT , CCK , and GLP-1 are heat stress-related biomarkers in adaptive organs that help in assessing the climate resilience of a livestock species and improving understanding about adaptive mechanisms. Among these biomarkers, HSP70 was established to be the ideal cellular biomarker for scaling heat response in livestock. Thus, examining heat-stressed organ histopathology and identifying cellular markers by immunohistochemistry may lay the foundation for screening climate-resilient livestock breeds in the challenging climatic scenario. Further, such an approach could help in developing concepts to combat the detrimental consequences of heat stress to ensure sustainability in livestock production.

Keywords: heat stress; histopathology; HSP70; immunohistochemistry; livestock (search for similar items in EconPapers)
JEL-codes: O13 Q Q0 Q2 Q3 Q5 Q56 (search for similar items in EconPapers)
Date: 2023
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