Beta-Lactam Susceptibility Profiles of Bacteria Isolated from the Ozama River in Santo Domingo, Dominican Republic

Roberto Bonnelly, Ana Lidia Queiroz Cavalcante, Victor V. Calderon, Rafael Azevedo Baraúna, Rommel Thiago Jucá Ramos, Yaset Rodríguez-Rodríguez, Luis Enrique Rodríguez De Francisco, Luis Orlando Maroto Martín, Omar Paino Perdomo and Edian Franklin Franco De Los Santos ()
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Roberto Bonnelly: Departament Basic and Environmental Science, Instituto Tecnológico de Santo Domingo (INTEC), Santo Domingo 10602, Dominican Republic
Ana Lidia Queiroz Cavalcante: Institute of Biological Sciences, Federal University of Pará-UFPA, Belem 66077-830, Brazil
Victor V. Calderon: Departament Basic and Environmental Science, Instituto Tecnológico de Santo Domingo (INTEC), Santo Domingo 10602, Dominican Republic
Rafael Azevedo Baraúna: Institute of Biological Sciences, Federal University of Pará-UFPA, Belem 66077-830, Brazil
Rommel Thiago Jucá Ramos: Institute of Biological Sciences, Federal University of Pará-UFPA, Belem 66077-830, Brazil
Yaset Rodríguez-Rodríguez: Departament Basic and Environmental Science, Instituto Tecnológico de Santo Domingo (INTEC), Santo Domingo 10602, Dominican Republic
Luis Enrique Rodríguez De Francisco: Departament Basic and Environmental Science, Instituto Tecnológico de Santo Domingo (INTEC), Santo Domingo 10602, Dominican Republic
Luis Orlando Maroto Martín: Departament Basic and Environmental Science, Instituto Tecnológico de Santo Domingo (INTEC), Santo Domingo 10602, Dominican Republic
Omar Paino Perdomo: Departament Basic and Environmental Science, Instituto Tecnológico de Santo Domingo (INTEC), Santo Domingo 10602, Dominican Republic
Edian Franklin Franco De Los Santos: Departament Basic and Environmental Science, Instituto Tecnológico de Santo Domingo (INTEC), Santo Domingo 10602, Dominican Republic

Sustainability, 2023, vol. 15, issue 6, 1-16

Abstract: The spread and contamination of antimicrobial-resistant bacteria in ambient waters is an emerging concern in urban, rural, medical, and industrial settings. A large amount of domestic, hospital, and industrial wastewater discharged directly into the rivers through the different channels can turn them into extensive reservoirs of antibiotic-resistant bacteria. In the present study, surface water samples from three collection sites were analyzed, according to different levels of anthropogenic impacts, along the Ozama River, one of the most important rivers in the Dominican metropolitan area, a source of water and food for human consumption. Seventy-six bacterial isolates were selected based on resistance to beta-lactams, using culture media previously enriched with cefotaxime and imipenem. Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF) subsequently identified them. The isolates covered 12 genera of bacteria; more than 30% were clinically relevant, and 43% had phenotypes classified as multidrug resistance. A total of 10 (44%) presented resistance. However, only seven presented resistance to 3 or more of the 14 groups of antibiotics, considered to be a multiresistant phenotype, which was sequenced using the high-throughput sequencing technique or New Generation (NGS). This study is part of the initiative to understand the profiles of the dangers of multidrug resistance in the metropolitan and rural areas of the Dominican Republic and its possible implications for human health.

Keywords: antimicrobial resistance; multi-drug resistance; Ozama River; Dominican Republic (search for similar items in EconPapers)
JEL-codes: O13 Q Q0 Q2 Q3 Q5 Q56 (search for similar items in EconPapers)
Date: 2023
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