Numerical Analysis of Sulfamerazine Solubility in Acetonitrile + 1-Propanol Cosolvent Mixtures at Different Temperatures

Claudia Patricia Ortiz, Rossember Edén Cardenas-Torres, Mauricio Herrera and Daniel Ricardo Delgado ()
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Claudia Patricia Ortiz: Programa de Administración en Seguridad y Salud en el Trabajo, Grupo de Investigación en Seguridad y Salud en el Trabajo, Corporación Universitaria Minuto de Dios-UNIMINUTO, Neiva 410001, Colombia
Rossember Edén Cardenas-Torres: Grupo de Fisicoquímica y Análisis Matemático, Facultad de Ciencias y Humanidades, Fundación Universidad de América, Bogotá 111221, Colombia
Mauricio Herrera: Programa de Ingeniería Civil, Grupo de Investigación de Ingenierías UCC-Neiva, Facultad de Ingeniería, Sede Neiva, Universidad Cooperativa de Colombia, Neiva 410001, Colombia
Daniel Ricardo Delgado: Programa de Ingeniería Civil, Grupo de Investigación de Ingenierías UCC-Neiva, Facultad de Ingeniería, Sede Neiva, Universidad Cooperativa de Colombia, Neiva 410001, Colombia

Sustainability, 2023, vol. 15, issue 8, 1-16

Abstract: The current challenges of the pharmaceutical industry regarding the environmental impact caused by its waste have led to the design and development of more efficient industrial processes. In this context, solubility studies are at the core of different processes, such as formulation, preformulation, synthesis, purification, recrystallization, quantification, and quality control. This research evaluates the solubility of sulfamerazine (SMR) in acetonitrile + 1-propanol cosolvent mixtures at nine temperature levels with UV/vis spectrophotometry using the vial-shake method. According to the analysis of the solid phase in equilibrium using differential scanning calorimetry, there were no polymorphic changes. The minimal solubility of SMR was reached in 1-propanol at 278.15 K, and the maximal solubility in acetonitrile at 313.15 K. In all cases, the process was endothermic and dependent on the cosolvent composition, and the solution enthalpy drove the solution process. The solubility data were well correlated with the van’t Hoff, Yalkowsky–Roseman–van’t Hoff, Apelblat, Buchowski–Ksiazczak λ h, Yaws, NRTL, Wilson, and modified Wilson models, with the YR model being one of the most attractive because it presented an excellent prediction percentage from four sets of experimental data. The solution process of SMR in acetonitrile + 1-propanol cosolvent mixtures depends on the affinity of SMR for acetonitrile and temperature increase.

Keywords: sulfamerazine; acetonitrile; 1-propanol; solubility; cosolvency; thermodynamics of solutions (search for similar items in EconPapers)
JEL-codes: O13 Q Q0 Q2 Q3 Q5 Q56 (search for similar items in EconPapers)
Date: 2023
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