Toxicological Response of Zebrafish Exposed to Cocktails of Polymeric Materials and Valproic Acid

Alexandra Savuca, Ionut-Alexandru Chelaru (), Ioana-Miruna Balmus, Alexandrina-Stefania Curpan, Mircea Nicusor Nicoara () and Alin Stelian Ciobica
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Alexandra Savuca: Doctoral School of Geosciences, Faculty of Geography and Geology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania
Ionut-Alexandru Chelaru: Doctoral School of Geosciences, Faculty of Geography and Geology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania
Ioana-Miruna Balmus: Doctoral School of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania
Alexandrina-Stefania Curpan: Doctoral School of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania
Mircea Nicusor Nicoara: Doctoral School of Geosciences, Faculty of Geography and Geology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania
Alin Stelian Ciobica: Department of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania

Sustainability, 2024, vol. 16, issue 5, 1-14

Abstract: Microplastic pollution represents an emerging problem of great interest in the public domain in the last decade; in addition, it overlaps with another delicate problem—pollution with pharmaceutical products that can have negative effects on the environment and people, even in small amounts. The main purpose of this study was to assess the biochemical and behavioral effects of exposure of adult zebrafish ( Danio rerio ) to polyethylene (PE), polypropylene (PP) and valproic acid (VPA), respectively to their mixtures—possible situations in natural aquatic environments. In terms of behavioral responses, sociability appears to be more impaired in the PP group after 5 days of exposure. The mechanisms affected are more those of swimming performance than of sociability. Even more, VPA increases presence in the arm with conspecifics but decreases mobility and locomotion, indicating a possible anxiety mechanism. The mixtures decrease the aggressiveness, especially in the case of the PE+VPA group, where it reaches a super low level compared to the control, which could endanger the species in nature. Regarding the anxiogenic effect, PP and PE act differently: if PE has an anxiogenic effect, on the opposite side is the PP group, which shows a bolder and more agitated behavior. All four variants showed behavioral changes indicative of toxicity from the first dose.

Keywords: microplastics; valproic acid; zebrafish; toxicity assessment (search for similar items in EconPapers)
JEL-codes: O13 Q Q0 Q2 Q3 Q5 Q56 (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:gam:jsusta:v:16:y:2024:i:5:p:2057-:d:1349731

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