Exposure and Early Effect Biomarkers for Risk Assessment of Occupational Exposure to Formaldehyde: A Systematic Review

Carmela Protano (), Arianna Antonucci, Andrea De Giorgi, Stefano Zanni, Elisa Mazzeo, Vincenzo Cammalleri, Leila Fabiani, Riccardo Mastrantonio, Mario Muselli, Giada Mastrangeli, Cinzia Lucia Ursini, Delia Cavallo, Diana Poli, Giorgia Di Gennaro, Giuseppe De Palma and Matteo Vitali
Additional contact information
Carmela Protano: Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Arianna Antonucci: Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Andrea De Giorgi: Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Stefano Zanni: Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Elisa Mazzeo: Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Vincenzo Cammalleri: Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Leila Fabiani: Department of Life, Health and Environmental Sciences, University of L’Aquila, P.le Salvatore Tommasi 1, Coppito, 67100 L’Aquila, Italy
Riccardo Mastrantonio: Department of Life, Health and Environmental Sciences, University of L’Aquila, P.le Salvatore Tommasi 1, Coppito, 67100 L’Aquila, Italy
Mario Muselli: Department of Life, Health and Environmental Sciences, University of L’Aquila, P.le Salvatore Tommasi 1, Coppito, 67100 L’Aquila, Italy
Giada Mastrangeli: Department of Life, Health and Environmental Sciences, University of L’Aquila, P.le Salvatore Tommasi 1, Coppito, 67100 L’Aquila, Italy
Cinzia Lucia Ursini: Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy
Delia Cavallo: Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy
Diana Poli: Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy
Giorgia Di Gennaro: Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Giuseppe De Palma: Unit of Occupational Health and Industrial Hygiene, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazzale Spdali Civili 1, 25123 Brescia, Italy
Matteo Vitali: Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy

Sustainability, 2024, vol. 16, issue 9, 1-19

Abstract: The aim of the present review was to identify all the biomarkers used for assessing the internal dose and the related early effects determined by the occupational exposure to formaldehyde. For this purpose, a systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The protocol was registered in PROSPERO (ID: CRD42023416960). An electronic search of Pubmed, Scopus, and Web of Science was performed to collect all the papers concerning the focus of the review and published from the inception of each database until 18 September 2023. Articles were considered eligible if they reported data from observational studies, semi-experimental, and experimental studies on adult workers who were occupationally exposed to formaldehyde, regardless of gender or age. The quality assessment was performed using the adapted Newcastle–Ottawa Quality Assessment Scale. From 1524 articles, 52 were included. Few studies assessed the exposure to formaldehyde in occupational settings through biomarkers, especially by measuring formic acid in urine. The most common approach for evaluating the effects derived from occupational exposure to formaldehyde was the use of the cytogenetic biomarker micronucleus assay in peripheral blood lymphocytes and/or epithelial buccal cells.

Keywords: workplaces; exposure; early effects; biomarkers; formaldehyde; systematic review (search for similar items in EconPapers)
JEL-codes: O13 Q Q0 Q2 Q3 Q5 Q56 (search for similar items in EconPapers)
Date: 2024
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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