Optimal Tolerance Design and Optimization for a Pharmaceutical Quality Characteristic

Seong Hoon Jeong, Pauline Kongsuwan, Nguyen Khoa Viet Truong and Sangmun Shin

Mathematical Problems in Engineering, 2013, vol. 2013, 1-17

Abstract:

A number of pharmaceutical quality characteristics are destructive or too costly to inspect. However, most quality improvement tools developed in the pharmaceutical research community typically assume that quality characteristics are nondestructive. This paper proposes a new design system for quality improvement by incorporating the concept of surrogate variables with the concepts of robust design (RD) and tolerance design (TD). The proposed robust-tolerance design paradigm determines the optimal factor setting and specification limits simultaneously, thereby improving quality of pharmaceutical products. In addition, the proposed methodology can provide the optimal tolerance as a mathematical closed-form solution. Finally, a numerical example and its associated sensitivity analysis for a pharmaceutical case are conducted for verification purposes. Based on the numerical example results, the proposed approach could provide robust factor settings with significant tradeoffs between quality and cost.

Date: 2013
References: Add references at CitEc
Citations:

Downloads: (external link)
http://downloads.hindawi.com/journals/MPE/2013/706962.pdf (application/pdf)
http://downloads.hindawi.com/journals/MPE/2013/706962.xml (text/xml)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:hin:jnlmpe:706962

DOI: 10.1155/2013/706962

Access Statistics for this article

More articles in Mathematical Problems in Engineering from Hindawi
Bibliographic data for series maintained by Mohamed Abdelhakeem ().