The Evaluation of Serum Il-6 Changes as Proliferative Cytokines in Patients With Nasopharyngeal Carcinoma Before and After the Ionizing Radiotherapy

Abdul Kadir, Kurnia Retnowati, M. Amsyar Akil and Andi Usman

Global Journal of Health Science, 2018, vol. 10, issue 8, 55

Abstract: BACKGROUND- Nasopharyngeal carcinoma is a squamous cell malignancy derived from the nasopharyngeal epithelial layer. This study aimed to calculate the IL-6 levels in patients with nasopharyngeal carcinoma before and after radiotherapy, in the week I and week 3 during the radiotherapy, and 2 weeks after the radiotherapy.METHODS- The study was conducted in a prospective cohort on 16 people suffering from nasopharyngeal carcinoma and undergoing radiotherapy, i.e. 9 patients were in stage I of nasopharyngeal carcinoma and 7 people were in stage II of nasopharyngeal carcinoma. Each sample underwent the examination of IL-6 before the week I and week 3 during the radiotherapy, and 2 weeks after the radio¬therapy.RESULTS- The more they received the treatment with radiotherapy the greater was the decrease of serum IL-6. The percentages of the decrease of the levels of serum IL-6 was greater in those receiving the 3-week duration of radiotherapy (24.59%) compared to those who just received 1-week duration of radiotherapy (6.44%). The decrease of serum IL-6 would continue, although radio-therapy had ended; 2 weeks after the radio-therapy, the percentage of serum IL-6 decreased to 42.43% from the level of serum IL-6 before the radio-therapy.CONCLUSIONS- The research results indicated that there happened a significant decrease of serum IL-6 (p<0.05) after the treatment with the radio-therapy

Date: 2018
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