Synthesis of Analogues of Natural Product ‘Antheminone A’ and Evaluation of Their Anti-Cancer Activity

Juliana Chineze Obi

International Journal of Chemistry, 2022, vol. 14, issue 2, 1-7

Abstract: Synthesis of two novel compounds (1a and 1b) derived from analogue of antheminone A (1c) and their evaluation of anti-cancer activities are hereby described. This synthesis involved a multi-step reaction sequence involving the use of natural product (-)-quinic acid (1d) and unsymmetrical dicoumarol (1e) as precursors (Figure 1). Unsymmetrical dicoumarol (1e), a potent inhibitor of NQO1 was synthesized by coupling 4-hydroxyl coumarin and an appropriate benzaldehyde. Thus, in order to facilitate drug penetration through the barriers of cell membrane to NQO1 location, compound (1e) was re-modified by coupling with an analogue of antheminone A (1c). Spectral analyses of the products were carried out in order to confirm the identity of the compounds. Interestingly, the compounds which were obtained in good to moderate yield (51-68%) exhibited toxicity against the non-small cancer cell line, A549.

Date: 2022
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://ccsenet.org/journal/index.php/ijc/article/download/0/0/47394/50800 (application/pdf)
https://ccsenet.org/journal/index.php/ijc/article/view/0/47394 (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:ibn:ijcjnl:14:y:2022:i:2:p:1-7

Access Statistics for this article

More articles in International Journal of Chemistry from Canadian Center of Science and Education Contact information at EDIRC.
Bibliographic data for series maintained by Canadian Center of Science and Education ().