Effect of Early Stimulation on Some Immune Parameters in a Model of Prenatally Stressed Rats

Ana Liaudat, Nancy Rodríguez, Adriana Vivas, Héctor Gauna and Nora Mayer

International Journal of Psychological Studies, 2012, vol. 4, issue 3, 73

Abstract: The aim of this research was to investigate the effects of prenatal stress and handling on immune system celldistribution and lymphocyte T proliferation in adult Albino Wistar male rats. Prenatal stressed (PS) offspring byimmobilization (IMO) were handled during the first week of life. Animals of both treatments were acute IMOstressed. Blood was extracted from 0 to 330 min, and counting of white blood cells, leucocyte subpopulationsand levels of corticosterone (COR) were made. Lymphocyte T spleen proliferation was determined. COR,leucocyte, lymphocyte and neutrophil profiles and lymphocyte T proliferation were significant different betweenprenatal stress and non-handling group and prenatal control and non-handling group, however these responseswere attenuated when animals were handled. In conclusion, early handling revert the effects of PS withre-exposure to the same postnatal stressor on the activity of hypothalamo-pituitary-adrenal axis, the dynamic ofleucocyte distribution and the mitogenic response of T lymphocytes.

Date: 2012
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