Screening of Myxobacteria Strains Producing Bioactive Substances against Breast Cancer

Hongpeng Wang, Liping Zhang and Nan Shi

Modern Applied Science, 2011, vol. 5, issue 1, 86

Abstract: [Objective] To screen myxobacteria strains producing secondary metabolites with anti-cancer activity. [Method] Fermentation culture the stains of myxobacteria, extract secondary metabolites with methanol, and detect the antitumor activity of secondary metabolites from myxobacteria and its toxicity to normal cells with the modified MTT (3-[4,5-dimethythiazol-2-yl] -2,5-diphenyltetrazolium bromide) method. [Results] Inhibition rate of myxobacteria strain 93431 fermentation original solutions, 2 fold dilution and 10 fold dilution on MCF-7 cells was 53.32%, 49.35%, and 46.50%, respectively, and their inhibition rate on MRC cells was 2.95%, 5.90%, and 1.97%, respectively. [Conclusion] Secondary metabolites produced from strains 93431 could inhibit MCF-7 cells specifically while had little effects on MRC cells and the bioactive substances from its secondary metabolites could be natural target anti-cancer agents.

Date: 2011
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://ccsenet.org/journal/index.php/mas/article/download/9215/6749 (application/pdf)
https://ccsenet.org/journal/index.php/mas/article/view/9215 (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:ibn:masjnl:v:5:y:2011:i:1:p:86

Access Statistics for this article

More articles in Modern Applied Science from Canadian Center of Science and Education Contact information at EDIRC.
Bibliographic data for series maintained by Canadian Center of Science and Education ().