Using a Case-Control Genotypic Testing in Investigating the Association with Type-2 Diabetes

Hajah Norhakimah Haji Mohd Nor and Masitah Shahrill

Modern Applied Science, 2014, vol. 8, issue 6, 1

Abstract: In the United Kingdom, Type-2 Diabetes (T2D) is the leading cause of blindness among working age adults. It is also known to cause kidney failure, amputations and cardiovascular diseases. In this study, genetic association tests were used to compare genetic variants carried by individuals against their disease status, with the aim to find genes that contributed to the risk of T2D. The identification of these genes could be of great importance especially in preventive healthcare measures. This study used a case-control genotypic test to find the association between Single Nucleotide Polymorphisms (SNPs) on chromosome 10 and T2D. SNPs are a type of polymorphism that occurs when a single nucleotide (A, C, G, and T) in the genome is substitute for another. At the beginning of the study, we had a total of 28,501 SNPs, however, 4,101 SNPs were removed after conducting both the Hardy Weinberg Equilibrium test and the control of Minor Allele Frequency in the preliminary analyses. These quality controls were done to remove SNPs that may lead to false associations. A total of 24,400 SNPs were left for association testing using the genotypic test of the contingency table. Our testing revealed that there were a total of 12 SNPs that had potential association with the risk of T2D.

Date: 2014
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