Ozone degradation of chloramphenicol: efficacy, products and toxicity

Junliang Wang, Wenshan Sun, Chao Xu and Weiping Liu

International Journal of Environmental Technology and Management, 2012, vol. 15, issue 2, 180-192

Abstract: The present work investigated the ozonation of chloramphenicol (CAP). Aqueous CAP was effectively removed by ozonation. The reaction intermediates or products were identified by liquid chromatography/mass spectrometry and ion chromatography. A possible degradation scheme was proposed based on the detected products. The change of antibiotic activity and acute toxicity of reaction mixtures was evaluated using E. coli and zebrafish embryo (Danio rerio) as tested organisms, respectively. The antibiotic activity decreased after ozonation, while the acute embryo toxicity increased in the first 120-min ozonation and subsequently decreased as the reaction prolonged.

Keywords: ozone degradation; chloramphenicol; toxicity; zebrafish embryo; antibiotic activity; ozonation; E. coli. (search for similar items in EconPapers)
Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:ids:ijetma:v:15:y:2012:i:2:p:180-192

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