Neural Networks for an Analysis of the Hemometabolites Biosensor Response

José Renato Garcia Braga, Alexandre Carlos Brandão Ramos, Alvaro Antonio Alencar de Queiroz, Demétrio Artur Werner Soares and Marília de Campos Bataglini
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José Renato Garcia Braga: Federal University of Itajubá, Itajubá, Minas Gerais, Brazil
Alexandre Carlos Brandão Ramos: Federal University of Itajubá, Itajubá, Minas Gerais, Brazil
Alvaro Antonio Alencar de Queiroz: Federal University of Itajubá, Itajubá, Minas Gerais, Brazil
Demétrio Artur Werner Soares: Federal University of Itajubá, Itajubá, Minas Gerais, Brazil
Marília de Campos Bataglini: Federal University of Itajubá, Itajubá, Minas Gerais, Brazil

International Journal of E-Health and Medical Communications (IJEHMC), 2013, vol. 4, issue 4, 84-101

Abstract: In this work, the concentration dependent response of amperometric biosensor array for the biomarkers glucose, cholesterol and urease was explored, using artificial neural nets (ANN). The aim was to explore an array of amperometric biosensors for the discrimination of the biomarkers glucose, cholesterol and urea in blood. Seven out of eight platinum electrodes on the array were modified with four different enzymes; glucose oxidase, cholesterol, urease and peroxidase. The dynamic biosensor response curves from the eight sensors were used for ANN analysis. The ANN were applied to an analysis of the biosensor response to multi-biomarkers mixtures the ANN was able to detect the conditions with an accuracy up to 90%. The results obtained by using ANN to interpret the electrical signal of the developed biosensor arrays leads to the conclusion that: i) after training the ANN, the evaluation of recorded data are on-line, ii) microelectrode sites which are highly correlated to the information about the concentrations within the recorded signals was identified, iii) the recognition of blood biomarkers is improved by using the ANN.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:igg:jehmc0:v:4:y:2013:i:4:p:84-101

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