Gene Polymorphisms and their Transcripts as Factors for Computerized Assessment of Fracture Risk: The Case of Postmenopausal Women with Osteoporosis

Panagiotis A. Adamopoulos, Abraham Pouliakis, Aris T. Spathis, Christine Kottaridi and Petros Karakitsos
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Panagiotis A. Adamopoulos: Orthopaedic Department, General Hospital of Attica Sismanoglio Amalia Fleming, Marousi, Greece
Abraham Pouliakis: Department of Cytopathology, Attikon University Hospital, University of Athens, Athens, Greece
Aris T. Spathis: Department of Cytopathology, Attikon University Hospital, University of Athens, Athens, Greece
Christine Kottaridi: Department of Cytopathology, Attikon University Hospital, University of Athens, Athens, Greece
Petros Karakitsos: Department of Cytopathology, Attikon University Hospital, University of Athens, Athens, Greece

International Journal of Reliable and Quality E-Healthcare (IJRQEH), 2015, vol. 4, issue 3, 27-46

Abstract: The aim of this study is the evaluation of osteoporosis related genes and transcription products, demographic and medication data for the estimation of fracture risk in women with osteoporosis. Such estimations are important for the creation of computerized applications similar to the Fracture Risk Assessment Tool (FRAX®). Low cost Internet based tools were used for the creation of anonymised patient record stored in the Cloud, and for an interdisciplinary team to decide on patient inclusion via voice and video conference. 100 female patients with an osteoporotic fracture, on medication or not were included in the study. A series of seven biochemical parameters using the Luminex® technique were measured and genetic characteristics using the microarray Metabone® technique were analysed. The statistical analysis indicated that these new parameters can be important for the estimation of fracture risk; thus computer based risk estimation for fractures could be based on additional molecular data.

Date: 2015
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