The Study on Antioxidation and Mechanism of 2 - Bromo - 4'- Nitroacetophenone

Runze Han and Dongmei Tian

Journal of Biology and Life Science, 2018, vol. 9, issue 2, 1-8

Abstract: The 2-Bromo-4'-nitroacetophenone is an important compound which is widely used in the modification of methionine residues in alpha-chymotrypsin, organic synthesis materials and pharmaceutical intermediates. Our laboratory recently found that the 2-bromo-4'-nitroacetophenone can extend the lifespan of the C. elegans. Therefore, we want to know whether this compound has the anti-oxidative ability. In this paper, we used three different concentrations of 2-bromo-4'-nitroacetophenone to feed normal C. elegans and the mutants (daf-16). we found that 2-bromo-4'-nitroacetophenone has antioxidant effect and this effect is dependent on Insulin pathway.

Keywords: C. Elegans; 2-bromo-4'-nitroacetophenone; anti-oxidation (search for similar items in EconPapers)
Date: 2018
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