Socioeconomic inequalities in molecular risk for chronic diseases observed in young adulthood

Michael J. Shanahan, Steven W. Cole, Sudharshan Ravi, Justin Chumbley, Wenjia Xu, Cecilia Potente, Brandt Levitt, Julien Bodelet, Allison Aiello, Lauren Gaydosh and Kathleen Mullan Harris
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Michael J. Shanahan: a Jacobs Center for Productive Youth Development, University of Zürich, Zürich, CH 8050;; b Department of Sociology, University of Zürich, Zürich, CH 8050;
Steven W. Cole: c School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095;
Sudharshan Ravi: a Jacobs Center for Productive Youth Development, University of Zürich, Zürich, CH 8050;
Justin Chumbley: a Jacobs Center for Productive Youth Development, University of Zürich, Zürich, CH 8050;
Wenjia Xu: a Jacobs Center for Productive Youth Development, University of Zürich, Zürich, CH 8050;
Cecilia Potente: a Jacobs Center for Productive Youth Development, University of Zürich, Zürich, CH 8050;
Brandt Levitt: d Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516;
Julien Bodelet: a Jacobs Center for Productive Youth Development, University of Zürich, Zürich, CH 8050;
Allison Aiello: d Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516;
Lauren Gaydosh: e Department of Sociology, University of Texas at Austin, Austin, TX 78712;
Kathleen Mullan Harris: d Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516;; f Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3210

Proceedings of the National Academy of Sciences, 2022, vol. 119, issue 43, e2103088119

Abstract: The analysis of gene expression in peripheral whole blood of US young adults in their late 30s revealed socioeconomic status-based inequalities in the molecular underpinnings of the most common chronic conditions of aging. Associations involved immune, inflammatory, ribosomal, and metabolic pathways, and extra- and intra-cellular signaling. Body mass index was a plausible, sizable mediator of many associations. Results point to new ways of thinking about how social inequalities “get under the skin” and also call for renewed efforts to prevent chronic conditions of aging decades before diagnoses.

Keywords: social inequality; social genomics; biodemography; life-span development; social epidemiology (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nas:journl:v:119:y:2022:p:e2103088119

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