Testing fractional doses of COVID-19 vaccines

Witold Więcek, Amrita Ahuja, Esha Chaudhuri, Michael Kremer, Alexandre Simoes Gomes, Christopher Snyder, Alexander Tabarrok and Brandon Tan
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Witold Więcek: a Development Innovation Lab, University of Chicago, Chicago, IL 60637;
Amrita Ahuja: b Douglas B. Marshall Jr. Family Foundation, Houston, TX 77002;
Esha Chaudhuri: a Development Innovation Lab, University of Chicago, Chicago, IL 60637;
Michael Kremer: a Development Innovation Lab, University of Chicago, Chicago, IL 60637;; c Department of Economics, University of Chicago, Chicago, IL 60637;; d National Bureau of Economic Research, Cambridge, MA 02138;
Alexandre Simoes Gomes: a Development Innovation Lab, University of Chicago, Chicago, IL 60637;

Proceedings of the National Academy of Sciences, 2022, vol. 119, issue 8, e2116932119

Abstract: Switching to fractional doses could dramatically accelerate vaccination, and clinical evidence suggests that fractional doses of COVID-19 vaccines could be highly effective. However, there is uncertainty about the effectiveness of fractional doses. In this paper, we present the existing evidence and use epidemiological models to quantify benefits under various scenarios. We argue for more experimental or observational data to be collected urgently. Because switching to fractional dosing could dramatically accelerate vaccination, the potential benefits of further testing of fractional doses far outweigh the costs.

Keywords: COVID-19; vaccines; pandemic; fractional dosing; dose stretching (search for similar items in EconPapers)
Date: 2022
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Related works:
Working Paper: Testing fractional doses of COVID-19 vaccines (2021)
Working Paper: Testing Fractional doses of COVID-19 Vaccines (2021)
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Persistent link: https://EconPapers.repec.org/RePEc:nas:journl:v:119:y:2022:p:e2116932119

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