Social stressors associated with age-related T lymphocyte percentages in older US adults: Evidence from the US Health and Retirement Study

Eric T. Klopack, Eileen M. Crimmins, Steve W. Cole, Teresa E. Seeman and Judith E. Carroll
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Eric T. Klopack: a Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089;
Eileen M. Crimmins: a Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089;
Steve W. Cole: b Cousins Center for Psychoneuroimmunology, Jane & Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095;
Teresa E. Seeman: c Division of Geriatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095;
Judith E. Carroll: d Cousins Center for Psychoneuroimmunology, Department of Psychiatry & Biobehavioral Sciences, Jane & Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095

Proceedings of the National Academy of Sciences, 2022, vol. 119, issue 25, e2202780119

Abstract: As the world’s population of older adults increases, understanding disparities in age-related health is essential. Age-related changes in the immune system play a critical role in age-related morbidity and mortality. This study assesses associations between social stress and immunophenotypes as immune age phenotype markers for the first time in a national sample of older US adults. This study helps clarify mechanisms involved in accelerated development of the immune age phenotype, including socioeconomic and lifestyle factors and cytomegalovirus infection and reactivation. This study also identifies important points of intervention that may be useful in addressing inequalities in aging.

Keywords: socioeconomic status; immunosenescence; aging (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nas:journl:v:119:y:2022:p:e2202780119

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