Defect engineered bioactive transition metals dichalcogenides quantum dots

Xianguang Ding, Fei Peng, Jun Zhou, Wenbin Gong, Garaj Slaven, Kian Ping Loh, Chwee Teck Lim () and David Tai Leong ()
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Xianguang Ding: National University of Singapore
Fei Peng: National University of Singapore
Jun Zhou: National University of Singapore
Wenbin Gong: Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences
Garaj Slaven: National University of Singapore
Kian Ping Loh: National University of Singapore
Chwee Teck Lim: National University of Singapore
David Tai Leong: National University of Singapore

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Transition metal dichalcogenide (TMD) quantum dots (QDs) are fundamentally interesting because of the stronger quantum size effect with decreased lateral dimensions relative to their larger 2D nanosheet counterparts. However, the preparation of a wide range of TMD QDs is still a continual challenge. Here we demonstrate a bottom-up strategy utilizing TM oxides or chlorides and chalcogen precursors to synthesize a small library of TMD QDs (MoS2, WS2, RuS2, MoTe2, MoSe2, WSe2 and RuSe2). The reaction reaches equilibrium almost instantaneously (~10–20 s) with mild aqueous and room temperature conditions. Tunable defect engineering can be achieved within the same reactions by deviating the precursors’ reaction stoichiometries from their fixed molecular stoichiometries. Using MoS2 QDs for proof-of-concept biomedical applications, we show that increasing sulfur defects enhanced oxidative stress generation, through the photodynamic effect, in cancer cells. This facile strategy will motivate future design of TMDs nanomaterials utilizing defect engineering for biomedical applications.

Date: 2019
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DOI: 10.1038/s41467-018-07835-1

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