Ultrasensitive detection of miRNA with an antimonene-based surface plasmon resonance sensor

Tianyu Xue, Weiyuan Liang, Yawen Li, Yuanhui Sun, Yuanjiang Xiang, Yupeng Zhang, Zhigao Dai, Yanhong Duo, Leiming Wu, Kun Qi, Bannur Nanjunda Shivananju, Lijun Zhang (), Xiaoqiang Cui (), Han Zhang () and Qiaoliang Bao ()
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Tianyu Xue: Shenzhen University
Weiyuan Liang: Shenzhen University
Yawen Li: Jilin University
Yuanhui Sun: Jilin University
Yuanjiang Xiang: Shenzhen University
Yupeng Zhang: Shenzhen University
Zhigao Dai: Monash University
Yanhong Duo: Shenzhen University
Leiming Wu: Shenzhen University
Kun Qi: Shenzhen University
Bannur Nanjunda Shivananju: Shenzhen University
Lijun Zhang: Jilin University
Xiaoqiang Cui: Jilin University
Han Zhang: Shenzhen University
Qiaoliang Bao: Monash University

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract MicroRNA exhibits differential expression levels in cancer and can affect cellular transformation, carcinogenesis and metastasis. Although fluorescence techniques using dye molecule labels have been studied, label-free molecular-level quantification of miRNA is extremely challenging. We developed a surface plasmon resonance sensor based on two-dimensional nanomaterial of antimonene for the specific label-free detection of clinically relevant biomarkers such as miRNA-21 and miRNA-155. First-principles energetic calculations reveal that antimonene has substantially stronger interaction with ssDNA than the graphene that has been previously used in DNA molecule sensing, due to thanking for more delocalized 5s/5p orbitals in antimonene. The detection limit can reach 10 aM, which is 2.3–10,000 times higher than those of existing miRNA sensors. The combination of not-attempted-before exotic sensing material and SPR architecture represents an approach to unlocking the ultrasensitive detection of miRNA and DNA and provides a promising avenue for the early diagnosis, staging, and monitoring of cancer.

Date: 2019
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DOI: 10.1038/s41467-018-07947-8

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