A region-resolved mucosa proteome of the human stomach

Xiaotian Ni, Zhaoli Tan, Chen Ding, Chunchao Zhang, Lan Song, Shuai Yang, Mingwei Liu, Ru Jia, Chuanhua Zhao, Lei Song, Wanlin Liu, Quan Zhou, Tongqing Gong, Xianju Li, Yanhong Tai, Weimin Zhu, Tieliu Shi, Yi Wang, Jianming Xu (), Bei Zhen () and Jun Qin ()
Additional contact information
Xiaotian Ni: The Fifth Medical Center, General Hospital of PLA
Zhaoli Tan: The Fifth Medical Center, General Hospital of PLA
Chen Ding: National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
Chunchao Zhang: Baylor College of Medicine
Lan Song: National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
Shuai Yang: The Fifth Medical Center, General Hospital of PLA
Mingwei Liu: National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
Ru Jia: The Fifth Medical Center, General Hospital of PLA
Chuanhua Zhao: The Fifth Medical Center, General Hospital of PLA
Lei Song: National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
Wanlin Liu: National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
Quan Zhou: National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
Tongqing Gong: National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
Xianju Li: National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
Yanhong Tai: The Fifth Medical Center, General Hospital of PLA
Weimin Zhu: National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
Tieliu Shi: East China Normal University
Yi Wang: National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
Jianming Xu: The Fifth Medical Center, General Hospital of PLA
Bei Zhen: National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
Jun Qin: National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract The human gastric mucosa is the most active layer of the stomach wall, involved in food digestion, metabolic processes and gastric carcinogenesis. Anatomically, the human stomach is divided into seven regions, but the protein basis for cellular specialization is not well understood. Here we present a global analysis of protein profiles of 82 apparently normal mucosa samples obtained from living individuals by endoscopic stomach biopsy. We identify 6,258 high-confidence proteins and estimate the ranges of protein expression in the seven stomach regions, presenting a region-resolved proteome reference map of the near normal, human stomach. Furthermore, we measure mucosa protein profiles of tumor and tumor nearby tissues (TNT) from 58 gastric cancer patients, enabling comparisons between tumor, TNT, and normal tissue. These datasets provide a rich resource for the gastrointestinal tract research community to investigate the molecular basis for region-specific functions in mucosa physiology and pathology including gastric cancer.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/s41467-018-07960-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-07960-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-07960-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().