RETRACTED ARTICLE: Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression

Gui-fang Zhu, Yang-wei Xu, Jian Li, Hui-lin Niu, Wen-xia Ma, Jia Xu, Pei-rong Zhou, Xia Liu, Dan-li Ye, Xiao-rong Liu, Tao Yan, Wei-ke Zhai, Zhi-jun Xu, Chun Liu, Lei Wang, Hao Wang, Jia-mao Luo, Li Liu, Xuan-qi Li, Suiqun Guo, Hui-ping Jiang, Peng Shen, Hui-kuan Lin, Di-hua Yu, Yan-qing Ding () and Qing-ling Zhang ()
Additional contact information
Gui-fang Zhu: Southern Medical University
Yang-wei Xu: Southern Medical University
Jian Li: Southern Medical University
Hui-lin Niu: Southern Medical University
Wen-xia Ma: Southern Medical University
Jia Xu: Icahn School of Medicine at Mount Sinai
Pei-rong Zhou: Southern Medical University
Xia Liu: Southern Medical University
Dan-li Ye: Southern Medical University
Xiao-rong Liu: Southern Medical University
Tao Yan: Southern Medical University
Wei-ke Zhai: Southern Medical University
Zhi-jun Xu: Southern Medical University
Chun Liu: Southern Medical University
Lei Wang: Southern Medical University
Hao Wang: Southern Medical University
Jia-mao Luo: Southern Medical University
Li Liu: Southern Medical University
Xuan-qi Li: Southern Medical University
Suiqun Guo: Southern Medical University
Hui-ping Jiang: Southern Medical University
Peng Shen: Southern Medical University
Hui-kuan Lin: Wake Forest Baptist Medical Center
Di-hua Yu: The University of Texas, MD Anderson Cancer Center
Yan-qing Ding: Southern Medical University
Qing-ling Zhang: Southern Medical University

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in other tumors are unclear. Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in women and the second leading cause in men in the United States. We demonstrated that WTX frequently lost in CRC which was highly correlated with cell proliferation, tumor invasion and metastasis. Mechanistically, WTX loss disrupts the interaction between RhoGDIα and CDC42 by losing of the binding with RhoGDIα and triggers the activation of CDC42 and its downstream cascades, which promotes CRC development and liver metastasis. The aberrant upregulation of miR-20a/miR-106a were identified as the reason of WTX loss in CRC both in vivo and in vitro. These study defined the mechanism how miR-20a/miR-106a-mediated WTX loss regulates CRC progression and metastasis, and provided a potential therapeutic target for preventing CRC progression.

Date: 2019
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DOI: 10.1038/s41467-018-07998-x

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