Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis

Yuan He, Renee Bouwstra, Valerie R. Wiersma, Mathilde de Jong, Harm Lourens, Rudolf Fehrmann, Marco de Bruyn, Emanuele Ammatuna, Gerwin Huls, Tom van Meerten () and Edwin Bremer ()
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Yuan He: University Medical Center Groningen (UMCG)
Renee Bouwstra: University Medical Center Groningen (UMCG)
Valerie R. Wiersma: University Medical Center Groningen (UMCG)
Mathilde de Jong: University Medical Center Groningen (UMCG)
Harm Lourens: University Medical Center Groningen (UMCG)
Rudolf Fehrmann: University Medical Center Groningen (UMCG)
Marco de Bruyn: University Medical Center Groningen (UMCG)
Emanuele Ammatuna: University Medical Center Groningen (UMCG)
Gerwin Huls: University Medical Center Groningen (UMCG)
Tom van Meerten: University Medical Center Groningen (UMCG)
Edwin Bremer: University Medical Center Groningen (UMCG)

Nature Communications, 2019, vol. 10, issue 1, 1-8

Abstract: Abstract CD47 is a prominent new target in cancer immunotherapy, with antagonistic antibodies currently being evaluated in clinical trials. For effective evaluation of this strategy it is crucial to identify which patients are suited for CD47-targeted therapy. In this respect, expression of the pro-phagocytic signal SLAMF7 on both macrophages and cancer cells was recently reported to be a requisite for CD47 antibody-mediated phagocytosis. Here, we demonstrate that in fact SLAMF7 expression on cancer cells is not required and does not impact on CD47 antibody therapy. Moreover, SLAMF7 also does not impact on phagocytosis induction by CD20 antibody rituximab nor associates with overall survival of Diffuse Large B-Cell Lymphoma patients. In contrast, expression of CD47 negatively impacts on overall and progression free survival. In conclusion, cancer cell expression of SLAMF7 is not required for phagocytosis and, in contrast to CD47 expression, should not be used as selection criterion for CD47-targeted therapy.

Date: 2019
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DOI: 10.1038/s41467-018-08013-z

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