Single-cell transcriptomic analysis of mouse neocortical development

Lipin Loo, Jeremy M. Simon, Lei Xing, Eric S. McCoy, Jesse K. Niehaus, Jiami Guo, E. S. Anton and Mark J. Zylka ()
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Lipin Loo: The University of North Carolina at Chapel Hill
Jeremy M. Simon: The University of North Carolina at Chapel Hill
Lei Xing: The University of North Carolina at Chapel Hill
Eric S. McCoy: The University of North Carolina at Chapel Hill
Jesse K. Niehaus: The University of North Carolina at Chapel Hill
Jiami Guo: The University of North Carolina at Chapel Hill
E. S. Anton: The University of North Carolina at Chapel Hill
Mark J. Zylka: The University of North Carolina at Chapel Hill

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract The development of the mammalian cerebral cortex depends on careful orchestration of proliferation, maturation, and migration events, ultimately giving rise to a wide variety of neuronal and non-neuronal cell types. To better understand cellular and molecular processes that unfold during late corticogenesis, we perform single-cell RNA-seq on the mouse cerebral cortex at a progenitor driven phase (embryonic day 14.5) and at birth—after neurons from all six cortical layers are born. We identify numerous classes of neurons, progenitors, and glia, their proliferative, migratory, and activation states, and their relatedness within and across age. Using the cell-type-specific expression patterns of genes mutated in neurological and psychiatric diseases, we identify putative disease subtypes that associate with clinical phenotypes. Our study reveals the cellular template of a complex neurodevelopmental process, and provides a window into the cellular origins of brain diseases.

Date: 2019
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DOI: 10.1038/s41467-018-08079-9

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