A micro-dispenser for long-term storage and controlled release of liquids

Amin Kazemzadeh (), Anders Eriksson, Marc Madou and Aman Russom ()
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Amin Kazemzadeh: KTH Royal Institute of Technology
Anders Eriksson: KTH Royal Institute of Technology
Marc Madou: University of California
Aman Russom: KTH Royal Institute of Technology

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract The success of lab-on-a-chip systems may depend on a low-cost device that incorporates on-chip storage and fluidic operations. To date many different methods have been developed that cope separately with on-chip storage and fluidic operations e.g., hydrophobic and capillary valves pneumatic pumping and blister storage packages. The blister packages seem difficult to miniaturize and none of the existing liquid handling techniques despite their variety are capable of proportional repeatable dispensing. We report here on an inexpensive robust and scalable micro-dispenser that incorporates long-term storage and aliquoting of reagents on different microfluidics platforms. It provides long-term shelf-life for different liquids enables precise dispensing on lab-on-a-disc platforms and less accurate but proportional dispensing when operated by finger pressure. Based on this technology we introduce a method for automation of blood plasma separation and multi-step bioassay procedures. This micro-dispenser intends to facilitate affordable portable diagnostic devices and accelerate the commercialization of lab-on-a-chip devices.

Date: 2019
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DOI: 10.1038/s41467-018-08091-z

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