Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome

Byoungjae Kong, Seokoh Moon, Yuna Kim, Paul Heo, Younghun Jung, Seok-Hyeon Yu, Jinhyo Chung, Choongjin Ban, Yong Ho Kim, Paul Kim, Beom Jeung Hwang, Woo-Jae Chung, Yeon-Kyun Shin, Baik Lin Seong and Dae-Hyuk Kweon ()
Additional contact information
Byoungjae Kong: Sungkyunkwan University
Seokoh Moon: Sungkyunkwan University
Yuna Kim: Sungkyunkwan University
Paul Heo: Sungkyunkwan University
Younghun Jung: Sungkyunkwan University
Seok-Hyeon Yu: Sungkyunkwan University
Jinhyo Chung: Sungkyunkwan University
Choongjin Ban: Sungkyunkwan University
Yong Ho Kim: Sungkyunkwan University
Paul Kim: Yonsei University
Beom Jeung Hwang: Yonsei University
Woo-Jae Chung: Sungkyunkwan University
Yeon-Kyun Shin: Iowa State University
Baik Lin Seong: Yonsei University
Dae-Hyuk Kweon: Sungkyunkwan University

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Membrane-disrupting agents that selectively target virus versus host membranes could potentially inhibit a broad-spectrum of enveloped viruses, but currently such antivirals are lacking. Here, we develop a nanodisc incorporated with a decoy virus receptor that inhibits virus infection. Mechanistically, nanodiscs carrying the viral receptor sialic acid bind to influenza virions and are co-endocytosed into host cells. At low pH in the endosome, the nanodiscs rupture the viral envelope, trapping viral RNAs inside the endolysosome for enzymatic decomposition. In contrast, liposomes containing a decoy receptor show weak antiviral activity due to the lack of membrane disruption. The nanodiscs inhibit influenza virus infection and reduce morbidity and mortality in a mouse model. Our results suggest a new class of antivirals applicable to other enveloped viruses that cause irreversible physical damage specifically to virus envelope by viruses’ own fusion machine. In conclusion, the lipid nanostructure provides another dimension for antiviral activity of decoy molecules.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-018-08138-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08138-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-08138-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().