Cross-lineage protection by human antibodies binding the influenza B hemagglutinin

Yi Liu, Hyon-Xhi Tan, Marios Koutsakos, Sinthujan Jegaskanda, Robyn Esterbauer, Danielle Tilmanis, Malet Aban, Katherine Kedzierska, Aeron C. Hurt, Stephen J. Kent () and Adam K. Wheatley ()
Additional contact information
Yi Liu: University of Melbourne
Hyon-Xhi Tan: University of Melbourne
Marios Koutsakos: University of Melbourne
Sinthujan Jegaskanda: University of Melbourne
Robyn Esterbauer: University of Melbourne
Danielle Tilmanis: The Peter Doherty Institute for Infection and Immunity
Malet Aban: The Peter Doherty Institute for Infection and Immunity
Katherine Kedzierska: University of Melbourne
Aeron C. Hurt: University of Melbourne
Stephen J. Kent: University of Melbourne
Adam K. Wheatley: University of Melbourne

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Influenza B viruses (IBV) drive a significant proportion of influenza-related hospitalisations yet are understudied compared to influenza A. Current vaccines target the head of the viral hemagglutinin (HA) which undergoes rapid mutation, significantly reducing vaccine effectiveness. Improved vaccines to control IBV are needed. Here we developed novel IBV HA probes to interrogate humoral responses to IBV in humans. A significant proportion of IBV HA-specific B cells recognise both B/Victoria/2/87-like and B/Yamagata/16/88-like lineages in a distinct pattern of cross-reactivity. Monoclonal antibodies (mAbs) were reconstituted from IBV HA-specific B cells, including mAbs providing broad protection in murine models of lethal IBV infection. Protection was mediated by neutralising antibodies targeting the receptor binding domain, or via Fc-mediated functions of non-neutralising antibodies binding alternative epitopes including the IBV HA stem. This work defines antigenic cross-recognition between IBV lineages and provides guidance for the rational design of improved IBV vaccines for broad and durable protection.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-018-08165-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08165-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-08165-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().