The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann and Jane A. McKeating ()
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Xiaodong Zhuang: University of Oxford
Andrea Magri: University of Oxford
Michelle Hill: University of Oxford
Alvina G. Lai: University of Oxford
Abhinav Kumar: University of Oxford
Srinivasa Bhargav Rambhatla: University of Birmingham
Claire L. Donald: University of Glasgow
Andrea F. Lopez-Clavijo: The Babraham Institute
Simon Rudge: The Babraham Institute
Katherine Pinnick: University of Oxford
Wai Hoong Chang: University of Oxford
Peter A. C. Wing: University of Oxford
Ryan Brown: University of Birmingham
Ximing Qin: Anhui University
Peter Simmonds: University of Oxford
Thomas F. Baumert: Institut de Recherche sur les Maladies Virales et Hépatiques
David Ray: University of Manchester
Andrew Loudon: University of Manchester
Peter Balfe: University of Birmingham
Michael Wakelam: The Babraham Institute
Sam Butterworth: University of Manchester
Alain Kohl: University of Glasgow
Catherine L. Jopling: University of Nottingham
Nicole Zitzmann: University of Oxford
Jane A. McKeating: University of Oxford

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood. Here we demonstrate that the circadian components BMAL1 and REV-ERBα influence several steps in the hepatitis C virus (HCV) life cycle, including particle entry into hepatocytes and RNA genome replication. Genetic knock out of Bmal1 and over-expression or activation of REV-ERB with synthetic agonists inhibits the replication of HCV and the related flaviruses dengue and Zika via perturbation of lipid signaling pathways. This study highlights a role for the circadian clock component REV-ERBα in regulating flavivirus replication.

Date: 2019
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DOI: 10.1038/s41467-019-08299-7

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