A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation

Avy Violari (), Mark F. Cotton, Louise Kuhn, Diana B. Schramm, Maria Paximadis, Shayne Loubser, Sharon Shalekoff, Bianca Da Costa Dias, Kennedy Otwombe, Afaaf Liberty, James McIntyre, Abdel Babiker, Diana Gibb and Caroline T. Tiemessen ()
Additional contact information
Avy Violari: University of the Witwatersrand
Mark F. Cotton: Stellenbosch University
Louise Kuhn: Columbia University Medical Center
Diana B. Schramm: National Institute for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS)
Maria Paximadis: National Institute for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS)
Shayne Loubser: National Institute for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS)
Sharon Shalekoff: National Institute for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS)
Bianca Da Costa Dias: National Institute for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS)
Kennedy Otwombe: University of the Witwatersrand
Afaaf Liberty: University of the Witwatersrand
James McIntyre: Anova Health Institute
Abdel Babiker: University College London
Diana Gibb: University College London
Caroline T. Tiemessen: National Institute for Communicable Diseases (NICD), of the National Health Laboratory Service (NHLS)

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Understanding HIV remission in rare individuals who initiated antiretroviral therapy (ART) soon after infection and then discontinued, may inform HIV cure interventions. Here we describe features of virus and host of a perinatally HIV-1 infected child with long-term sustained virological control. The child received early limited ART in the Children with HIV Early antiRetroviral therapy (CHER) trial. At age 9.5 years, diagnostic tests for HIV are negative and the child has characteristics similar to uninfected children that include a high CD4:CD8 ratio, low T cell activation and low CCR5 expression. Virus persistence (HIV-1 DNA and plasma RNA) is confirmed with sensitive methods, but replication-competent virus is not detected. The child has weak HIV-specific antibody and T cell responses. Furthermore, we determine his HLA and KIR genotypes. This case aids in understanding post-treatment control and may help design of future intervention strategies.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-019-08311-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08311-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-08311-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().