The antimicrobial potential of Streptomyces from insect microbiomes

Marc G. Chevrette, Caitlin M. Carlson, Humberto E. Ortega, Chris Thomas, Gene E. Ananiev, Kenneth J. Barns, Adam J. Book, Julian Cagnazzo, Camila Carlos, Will Flanigan, Kirk J. Grubbs, Heidi A. Horn, F. Michael Hoffmann, Jonathan L. Klassen, Jennifer J. Knack, Gina R. Lewin, Bradon R. McDonald, Laura Muller, Weilan G. P. Melo, Adrián A. Pinto-Tomás, Amber Schmitz, Evelyn Wendt-Pienkowski, Scott Wildman, Miao Zhao, Fan Zhang, Tim S. Bugni, David R. Andes, Monica T. Pupo and Cameron R. Currie ()
Additional contact information
Marc G. Chevrette: University of Wisconsin-Madison
Caitlin M. Carlson: University of Wisconsin-Madison
Humberto E. Ortega: University of São Paulo
Chris Thomas: University of Wisconsin-Madison
Gene E. Ananiev: University of Wisconsin-Madison
Kenneth J. Barns: University of Wisconsin-Madison
Adam J. Book: University of Wisconsin-Madison
Julian Cagnazzo: University of Wisconsin-Madison
Camila Carlos: University of Wisconsin-Madison
Will Flanigan: University of Wisconsin-Madison
Kirk J. Grubbs: University of Wisconsin-Madison
Heidi A. Horn: University of Wisconsin-Madison
F. Michael Hoffmann: University of Wisconsin-Madison
Jonathan L. Klassen: University of Connecticut
Jennifer J. Knack: University of Minnesota-Duluth
Gina R. Lewin: Georgia Institute of Technology
Bradon R. McDonald: University of Wisconsin-Madison
Laura Muller: University of Wisconsin-Madison
Weilan G. P. Melo: University of São Paulo
Adrián A. Pinto-Tomás: University of Costa Rica
Amber Schmitz: University of Wisconsin-Madison
Evelyn Wendt-Pienkowski: University of Wisconsin-Madison
Scott Wildman: University of Wisconsin-Madison
Miao Zhao: University of Wisconsin School of Medicine and Public Health
Fan Zhang: University of Wisconsin-Madison
Tim S. Bugni: University of Wisconsin-Madison
David R. Andes: University of Wisconsin School of Medicine and Public Health
Monica T. Pupo: University of São Paulo
Cameron R. Currie: University of Wisconsin-Madison

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Antimicrobial resistance is a global health crisis and few novel antimicrobials have been discovered in recent decades. Natural products, particularly from Streptomyces, are the source of most antimicrobials, yet discovery campaigns focusing on Streptomyces from the soil largely rediscover known compounds. Investigation of understudied and symbiotic sources has seen some success, yet no studies have systematically explored microbiomes for antimicrobials. Here we assess the distinct evolutionary lineages of Streptomyces from insect microbiomes as a source of new antimicrobials through large-scale isolations, bioactivity assays, genomics, metabolomics, and in vivo infection models. Insect-associated Streptomyces inhibit antimicrobial-resistant pathogens more than soil Streptomyces. Genomics and metabolomics reveal their diverse biosynthetic capabilities. Further, we describe cyphomycin, a new molecule active against multidrug resistant fungal pathogens. The evolutionary trajectories of Streptomyces from the insect microbiome influence their biosynthetic potential and ability to inhibit resistant pathogens, supporting the promise of this source in augmenting future antimicrobial discovery.

Date: 2019
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DOI: 10.1038/s41467-019-08438-0

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