The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine

Hyoung-Soo Cho, Andrea Reboldi, Jason A. Hall and Leslie J. Berg ()
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Hyoung-Soo Cho: University of Massachusetts Medical School
Andrea Reboldi: University of Massachusetts Medical School
Jason A. Hall: New York University School of Medicine
Leslie J. Berg: University of Massachusetts Medical School

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Innate lymphoid cells (ILC) are lymphocytes that lack an antigen-specific receptor and are preferentially localized in non-lymphoid tissues, such as mucosal barriers. In these locations ILC respond to tissue perturbations by producing factors that promote tissue repair and improve barrier integrity. We show that mice lacking the Tec kinase ITK have impaired intestinal tissue integrity, and a reduced ability to restore homeostasis after tissue damage. This defect is associated with a substantial loss of Type 2 ILC (ILC2) in the intestinal lamina propria. Adoptive transfer of bone marrow ILC2 precursors confirms a cell-intrinsic role for ITK. Intestinal ILC2 numbers in Itk-/- mice are restored by the administration of IL-2 complexes, also leading to improved intestinal tissue damage repair. Reduced Bcl-2 expression in intestinal Itk-/- ILC2 is also restored to WT levels after IL-2 complex treatment, indicating a tissue-specific role for ITK in ILC2 survival in the intestine.

Date: 2019
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DOI: 10.1038/s41467-019-08699-9

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