Multi-cohort study identifies social determinants of systemic inflammation over the life course

Eloïse Berger, Raphaële Castagné, Marc Chadeau-Hyam, Murielle Bochud, Angelo d’Errico, Martina Gandini, Maryam Karimi, Mika Kivimäki, Vittorio Krogh, Michael Marmot, Salvatore Panico, Martin Preisig, Fulvio Ricceri, Carlotta Sacerdote, Andrew Steptoe, Silvia Stringhini, Rosario Tumino, Paolo Vineis, Cyrille Delpierre and Michelle Kelly-Irving ()
Additional contact information
Eloïse Berger: Inserm-Université Toulouse III Paul Sabatier
Raphaële Castagné: Inserm-Université Toulouse III Paul Sabatier
Marc Chadeau-Hyam: Imperial College London
Murielle Bochud: Lausanne University Hospital
Angelo d’Errico: ASL TO3 Piedmont Region
Martina Gandini: ASL TO3 Piedmont Region
Maryam Karimi: Imperial College London
Mika Kivimäki: University College London
Vittorio Krogh: Fondazione IRCCS Istituto Nazionale dei Tumori
Michael Marmot: University College London
Salvatore Panico: University of Naples Federico II
Martin Preisig: Lausanne University Hospital
Fulvio Ricceri: ASL TO3 Piedmont Region
Carlotta Sacerdote: Piedmont Reference Centre for Epidemiology and Cancer Prevention (CPO Piemonte)
Andrew Steptoe: University College London
Silvia Stringhini: Lausanne University Hospital
Rosario Tumino: ‘Civic – M. P. Arezzo’ Hospital, ASP Ragusa
Paolo Vineis: Imperial College London
Cyrille Delpierre: Inserm-Université Toulouse III Paul Sabatier
Michelle Kelly-Irving: Inserm-Université Toulouse III Paul Sabatier

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation is key in elucidating biological mechanisms underlying socioeconomic disparities. Here we explore the relationship between socioeconomic position (SEP) across the life course and inflammation (as measured by CRP levels) in up to 23,008 participants from six European cohort studies from three countries conducted between 1958 and 2013. We find a consistent inverse association between SEP and CRP across cohorts, where participants with a less advantaged SEP have higher levels of inflammation. Educational attainment is most strongly related to inflammation, after adjusting for health behaviours, body mass index and later-in-life SEP. These findings suggest socioeconomic disadvantage in young adulthood is independently associated with later life inflammation calling for further studies of the pathways operating through educational processes.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08732-x

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DOI: 10.1038/s41467-019-08732-x

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