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Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Amy H. Lee, Casey P. Shannon, Nelly Amenyogbe, Tue B. Bennike, Joann Diray-Arce, Olubukola T. Idoko, Erin E. Gill, Rym Ben-Othman, William S. Pomat, Simon D. Haren, Kim-Anh Lê Cao, Momoudou Cox, Alansana Darboe, Reza Falsafi, Davide Ferrari, Daniel J. Harbeson, Daniel He, Cai Bing, Samuel J. Hinshaw, Jorjoh Ndure, Jainaba Njie-Jobe, Matthew A. Pettengill, Peter C. Richmond, Rebecca Ford, Gerard Saleu, Geraldine Masiria, John Paul Matlam, Wendy Kirarock, Elishia Roberts, Mehrnoush Malek, Guzmán Sanchez-Schmitz, Amrit Singh, Asimenia Angelidou, Kinga K. Smolen, Ryan R. Brinkman, Al Ozonoff, Robert E. W. Hancock, Anita H. J. Biggelaar, Hanno Steen, Scott J. Tebbutt, Beate Kampmann, Ofer Levy () and Tobias R. Kollmann ()
Additional contact information
Amy H. Lee: University of British Columbia
Casey P. Shannon: PROOF Centre of Excellence
Nelly Amenyogbe: University of British Columbia
Tue B. Bennike: Boston Children’s Hospital
Joann Diray-Arce: Boston Children’s Hospital
Olubukola T. Idoko: Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
Erin E. Gill: University of British Columbia
Rym Ben-Othman: University of British Columbia
William S. Pomat: Papua New Guinea Institute of Medical Research
Simon D. Haren: Boston Children’s Hospital
Kim-Anh Lê Cao: The University of Melbourne
Momoudou Cox: Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
Alansana Darboe: Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
Reza Falsafi: University of British Columbia
Davide Ferrari: The University of Melbourne
Daniel J. Harbeson: University of British Columbia
Daniel He: PROOF Centre of Excellence
Cai Bing: University of British Columbia
Samuel J. Hinshaw: University of British Columbia
Jorjoh Ndure: Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
Jainaba Njie-Jobe: Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
Matthew A. Pettengill: Boston Children’s Hospital
Peter C. Richmond: Division of Paediatrics, School of Medicine, University of Western Australia
Rebecca Ford: Papua New Guinea Institute of Medical Research
Gerard Saleu: Papua New Guinea Institute of Medical Research
Geraldine Masiria: Papua New Guinea Institute of Medical Research
John Paul Matlam: Papua New Guinea Institute of Medical Research
Wendy Kirarock: Papua New Guinea Institute of Medical Research
Elishia Roberts: Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
Mehrnoush Malek: BC Cancer Agency
Guzmán Sanchez-Schmitz: Boston Children’s Hospital
Amrit Singh: PROOF Centre of Excellence
Asimenia Angelidou: Boston Children’s Hospital
Kinga K. Smolen: Boston Children’s Hospital
Ryan R. Brinkman: BC Cancer Agency
Al Ozonoff: Boston Children’s Hospital
Robert E. W. Hancock: University of British Columbia
Anita H. J. Biggelaar: University of Western Australia Perth
Hanno Steen: Boston Children’s Hospital
Scott J. Tebbutt: PROOF Centre of Excellence
Beate Kampmann: Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
Ofer Levy: Boston Children’s Hospital
Tobias R. Kollmann: University of British Columbia

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from

Date: 2019
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DOI: 10.1038/s41467-019-08794-x

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