Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika

Paulina Andrade, Ciara Gimblet-Ochieng, Faraz Modirian, Matthew Collins, Maritza Cárdenas, Leah C. Katzelnick, Magelda Montoya, Daniela Michlmayr, Guillermina Kuan, Angel Balmaseda, Josefina Coloma, Aravinda M. Silva and Eva Harris ()
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Paulina Andrade: University of California, Berkeley
Ciara Gimblet-Ochieng: University of North Carolina
Faraz Modirian: University of California, Berkeley
Matthew Collins: University of North Carolina
Maritza Cárdenas: University of California, Berkeley
Leah C. Katzelnick: University of California, Berkeley
Magelda Montoya: University of California, Berkeley
Daniela Michlmayr: University of California, Berkeley
Guillermina Kuan: Centro de Salud Sócrates Flores Vivas, Ministry of Health
Angel Balmaseda: Sustainable Sciences Institute
Josefina Coloma: University of California, Berkeley
Aravinda M. Silva: University of North Carolina
Eva Harris: University of California, Berkeley

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Little is known about enduring memory B cell (MBC) responses to Zika virus (ZIKV) and their relationship with circulating antibodies. Here we comprehensively assess MBC frequency and specificity alongside serum binding and neutralizing antibody responses to ZIKV ~2 weeks and ~8 months postinfection in 31 pediatric subjects with 0, 1 or >1 prior infections with the related dengue virus (DENV). ZIKV infection elicits a robust type-specific MBC response, and the majority of late convalescent anti-ZIKV serum neutralizing activity is attributable to ZIKV-specific antibodies. The number of prior DENV infections does not influence type-specific or cross-reactive MBC responses, although ZIKV has the highest cross-reactivity with DENV3. DENV cross-reactive MBCs expanded by ZIKV infection decline in number and proportion by late convalescence. Finally, ZIKV induces greater cross-reactivity in the MBC pool than in serum antibodies. Our data suggest immunity to DENV only modestly shapes breadth and magnitude of enduring ZIKV antibody responses.

Date: 2019
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DOI: 10.1038/s41467-019-08845-3

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