Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation

Julia O’Sullivan, Maria Tedim Ferreira, Jean-Philippe Gagné, Ajit K. Sharma, Michael J. Hendzel (), Jean-Yves Masson () and Guy G. Poirier ()
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Julia O’Sullivan: Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, HDQ Pavilion, Oncology Division
Maria Tedim Ferreira: Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, HDQ Pavilion, Oncology Division
Jean-Philippe Gagné: Université Laval
Ajit K. Sharma: University of Alberta
Michael J. Hendzel: University of Alberta
Jean-Yves Masson: Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, HDQ Pavilion, Oncology Division
Guy G. Poirier: Université Laval

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Protein ADP-ribosylation is essential for the regulation of several cellular pathways, enabling dynamic responses to diverse pathophysiological conditions. It is modulated through a dynamic interplay between ADP-ribose readers, writers and erasers. While ADP-ribose synthesis has been studied and reviewed extensively, ADP-ribose processing by erasing enzymes has received comparably less attention. However, major progress in the mass spectrometric identification of ADP-ribosylated residues and the biochemical characterization of ADP-ribose erasers has substantially expanded our knowledge of ADP-ribosylation dynamics. Herein, we describe recent insights into the biology of ADP-ribose erasers and discuss the intricately orchestrated cellular processes to switch off ADP-ribose-dependent mechanisms.

Date: 2019
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DOI: 10.1038/s41467-019-08859-x

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