Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Hassan S. Dashti, Samuel E. Jones, Andrew R. Wood, Jacqueline M. Lane, Vincent T. Hees, Heming Wang, Jessica A. Rhodes, Yanwei Song, Krunal Patel, Simon G. Anderson, Robin N. Beaumont, David A. Bechtold, Jack Bowden, Brian E. Cade, Marta Garaulet, Simon D. Kyle, Max A. Little, Andrew S. Loudon, Annemarie I. Luik, Frank A. J. L. Scheer, Kai Spiegelhalder, Jessica Tyrrell, Daniel J. Gottlieb, Henning Tiemeier, David W. Ray, Shaun M. Purcell, Timothy M. Frayling, Susan Redline, Deborah A. Lawlor, Martin K. Rutter, Michael N. Weedon and Richa Saxena ()
Additional contact information
Hassan S. Dashti: Massachusetts General Hospital and Harvard Medical School
Samuel E. Jones: University of Exeter Medical School
Andrew R. Wood: University of Exeter Medical School
Jacqueline M. Lane: Massachusetts General Hospital and Harvard Medical School
Vincent T. Hees: Netherlands eScience Center
Heming Wang: Broad Institute
Jessica A. Rhodes: Massachusetts General Hospital and Harvard Medical School
Yanwei Song: Massachusetts General Hospital and Harvard Medical School
Krunal Patel: Massachusetts General Hospital and Harvard Medical School
Simon G. Anderson: The University of Manchester
Robin N. Beaumont: University of Exeter Medical School
David A. Bechtold: University of Manchester
Jack Bowden: MRC Integrative Epidemiology Unit at the University of Bristol
Brian E. Cade: Broad Institute
Marta Garaulet: University of Murcia
Simon D. Kyle: University of Oxford
Max A. Little: Aston University
Andrew S. Loudon: University of Manchester
Annemarie I. Luik: University of Oxford
Frank A. J. L. Scheer: Broad Institute
Kai Spiegelhalder: University of Freiburg
Jessica Tyrrell: University of Exeter Medical School
Daniel J. Gottlieb: Brigham and Women’s Hospital
Henning Tiemeier: Harvard TH Chan School of Public Health
David W. Ray: University of Manchester
Shaun M. Purcell: Harvard Medical School
Timothy M. Frayling: University of Exeter Medical School
Susan Redline: Harvard Medical School
Deborah A. Lawlor: MRC Integrative Epidemiology Unit at the University of Bristol
Martin K. Rutter: University of Manchester
Michael N. Weedon: University of Exeter Medical School
Richa Saxena: Massachusetts General Hospital and Harvard Medical School

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration (p

Date: 2019
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DOI: 10.1038/s41467-019-08917-4

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