Control of capillary behavior through target-responsive hydrogel permeability alteration for sensitive visual quantitative detection

Yansheng Li, Yanli Ma, Xiangyu Jiao, Tingyu Li, Zhehao Lv, Chaoyong James Yang (), Xueji Zhang () and Yongqiang Wen ()
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Yansheng Li: University of Science and Technology Beijing
Yanli Ma: Xiamen University
Xiangyu Jiao: University of Science and Technology Beijing
Tingyu Li: Xiamen University
Zhehao Lv: Xiamen University
Chaoyong James Yang: Xiamen University
Xueji Zhang: University of Science and Technology Beijing
Yongqiang Wen: University of Science and Technology Beijing

Nature Communications, 2019, vol. 10, issue 1, 1-8

Abstract: Abstract DNA hydrogels have received considerable attention in analytical science, however, some limitations still exist in the applications of intelligent hydrogels. In this paper, we describe a way to prepare gel film in a capillary tube based on the thermal reversible principle of DNA hydrogel and the principle of capillary action. Because of the slight change in the internal structure of gel, its permeability can be increased by the addition of some specific targets. The capillary behavior is thus changed due to the different permeability of the hydrogel film. The duration time of the target solution flowing through the capillary tube with a specified length is used to quantify this change. With this proposed method, ultra-trace DNA hydrogel (0.01 μL) is sufficient to realize the sensitive detection of cocaine without the aid of other instruments, which has a low detection limit (1.17 nM) and good selectivity.

Date: 2019
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DOI: 10.1038/s41467-019-08952-1

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