Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target

Sung-Jin Park, Beomsue Kim, Sejong Choi, Sivaraman Balasubramaniam, Sung-Chan Lee, Jung Yeol Lee, Heon Seok Kim, Jun-Young Kim, Jong-Jin Kim, Yong-An Lee, Nam-Young Kang, Jin-Soo Kim () and Young-Tae Chang ()
Additional contact information
Sung-Jin Park: Agency for Science, Technology and Research
Beomsue Kim: Agency for Science, Technology and Research
Sejong Choi: Seoul National University
Sivaraman Balasubramaniam: Agency for Science, Technology and Research
Sung-Chan Lee: Agency for Science, Technology and Research
Jung Yeol Lee: Pohang University of Science and Technology (POSTECH)
Heon Seok Kim: Seoul National University
Jun-Young Kim: Agency for Science, Technology and Research
Jong-Jin Kim: Agency for Science, Technology and Research
Yong-An Lee: Agency for Science, Technology and Research
Nam-Young Kang: Agency for Science, Technology and Research
Jin-Soo Kim: Seoul National University
Young-Tae Chang: Agency for Science, Technology and Research

Nature Communications, 2019, vol. 10, issue 1, 1-7

Abstract: Abstract Activated macrophages have the potential to be ideal targets for imaging inflammation. However, probe selectivity over non-activated macrophages and probe delivery to target tissue have been challenging. Here, we report a small molecule probe specific for activated macrophages, called CDg16, and demonstrate its application to visualizing inflammatory atherosclerotic plaques in vivo. Through a systematic transporter screen using a CRISPR activation library, we identify the orphan transporter Slc18b1/SLC18B1 as the gating target of CDg16.

Date: 2019
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DOI: 10.1038/s41467-019-08990-9

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