A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome

Akira Wiberg, Michael Ng, Annina B. Schmid, Robert W. Smillie, Georgios Baskozos, Michael V. Holmes, K. Künnapuu, R. Mägi, David L. Bennett () and Dominic Furniss ()
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Akira Wiberg: University of Oxford, Botnar Research Centre
Michael Ng: University of Oxford, Botnar Research Centre
Annina B. Schmid: University of Oxford, John Radcliffe Hospital
Robert W. Smillie: University of Oxford, Botnar Research Centre
Georgios Baskozos: University of Oxford, John Radcliffe Hospital
Michael V. Holmes: Medical Research Council Population Health Research Unit at the University of Oxford
K. Künnapuu: University of Tartu
R. Mägi: University of Tartu
David L. Bennett: University of Oxford, John Radcliffe Hospital
Dominic Furniss: University of Oxford, Botnar Research Centre

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Carpal tunnel syndrome (CTS) is a common and disabling condition of the hand caused by entrapment of the median nerve at the level of the wrist. It is the commonest entrapment neuropathy, with estimates of prevalence ranging between 5–10%. Here, we undertake a genome-wide association study (GWAS) of an entrapment neuropathy, using 12,312 CTS cases and 389,344 controls identified in UK Biobank. We discover 16 susceptibility loci for CTS with p

Date: 2019
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DOI: 10.1038/s41467-019-08993-6

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